풀미코트
약을 팔자! 풀미코트 Pulmicort respule
용량 0.5mg/2ml
요약 : 원내 네뷸라이저 용액에 한개씩 까서 섞으면 될듯. BID 가능하고 SID 도 가능하다. 하지만 보호자에게 처방용으로 계속 나가기에는 개에서 계속 써도 된다는 연구결과가 없으므로 주의.
개 IBD: 3 mg/m2 PO q 24h (not to exceed 3 mg), or 0.5-3 mg/DOG q 24h
고양이 IBD: 1 mg/CAT PO q 24h
고양이 Asthma: 400 mcg inhaled q 12h
- 사람에서는 HPA 에 미치는 영향이 거의 없다라는 연구결과가 있음. (맨날 쓰면 됨)
(Once-daily budesonide inhalation suspension is effective in the treatment of persistent asthma in children aged <4 and ≥4 years of age.)
- 하지만 개에서는 스테로이드 관련 부작용이 일어날수 있다.[cote]
(Although budesonide causes less suppression of the HPA axis in humans, this may not be the case in dogs. Adverse effects associated with other glucocorticoid types can be seen. [cote])
- 4주 이용시 안전하다는 논문은 있음.
- The HPA axis was strongly suppressed after 4 weeks treatment with FP or prednisolone, but not BUD, at clinically relevant doses in healthy dogs. These findings suggested that inhaled BUD may be a safer choice in the treatment of chronic respiratory diseases in dogs sensitive to the systemic adverse effects of corticosteroid treatment. However, further studies are required to assess the therapeutic doses of ICSs in dogs and to compare the systemic adverse effects of dosages with equivalent clinical efficacy. (Marika Melamies et al, 2012, 헬싱키, Finland)
- 케토 이트라등 cyp3a4 억제제와 병용투여 피해야 한다.
- 비싸다
[참고] 흡입 챔버 쓰는 법.
일반적으로 약물을 한번 분사시키고 5-10회 호흡하면 충분하다.
2회 이상 분사가 필요한 경우에는 한꺼번에 여러 번 분사하지 않고 1회 분사 후 5-10회 흡입하는 방법을 반복한다.
budesonide
0.5mg/2ml
분무기의 적당한 충진용량은 2-5 밀리리터
소아는 0.5~1병을 1일 2회 투여한다.
(1) budesonide inhalation (200 μg twice daily); (2) fluticasone inhalation (250 μg twice daily); (3) oral prednisolone (1mg/kg once daily); and (4) placebo inhalation (room air twice daily)
wash-out period lasted 4 weeks.
The HPA axis was strongly suppressed after 4 weeks treatment with FP or prednisolone, but not BUD, at clinically relevant doses in healthy dogs.These findings suggested that inhaled BUD may be a safer choice in the treatment of chronic respiratory diseases in dogs sensitive to the systemic adverse effects of corticosteroid treatmentㄹ
Synthesis and release of glucocorticoids is regulated by the
hypothalamic-pituitary-adrenal (HPA) axis in a circadian manner and levels
increase in response to stress.