Firocoxib (Previcox)

nsaid, steroid 의 wash out period

[이하 출처] https://www.merckvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals?query=firocoxib%20cat#v3337716

Meloxicam (제품명 : 메타캄) PG 합성을 막는다. 

[개에서]

 treatment of acute and chronic inflammation associated with musculoskeletal disease and for the management of postoperative pain

 In dogs, a one-time loading dose of 0.2 mg/kg, PO, is recommended, followed by 0.1 mg/kg per day, PO. Once a therapeutic effect occurs, the dosage can be titrated to the lowest possible dose.

2.7- to 10-fold more selective for COX-2.

, meloxicam is highly protein bound (97%) and has a relatively long elimination half-life (>12 hours).

[고양이에서]

 meloxicam undergoes oxidative metabolism, not glucuronidation, with 80% of the drug excreted in feces.

 In the US, meloxicam is not approved for use in cats beyond a single injection

whereas in the EU and other countries the oral suspension is registered for multiple administration in cats, with a label maintenance dose of 0.05 mg/kg.

 There is considerable evidence that low-dose meloxicam (0.02 mg/kg) is relatively well tolerated and safe for chronic administration in cats, including those with chronic kidney disease (although staging and thorough patient evaluation before this use is prudent).